The c‐myc proto‐oncogene is believed to be involved in the regulation of cell growth and differentiation. Deregulation of this gene, resulting in an inappropriate increase of gene product, can contribute to cancer formation. One of the ways in which the expression of the c‐myc gene can be deregulated is by the stabilization of the labile c‐myc mRNA. The rapid degradation of the c‐myc transcript appears to be mediated by at least two distinct regions in the mRNA. One lies in the (...) 3' untranslated region, and presumably consists of (A+U)‐rich sequences. The other lies in the C‐terminal part of the coding region and colocalizes with sequences encoding protein‐dimerization motifs. The exact mechanism by which the destabilizing elements function is not yet clear. Shortening of the poly(A) tail of the c‐myc message appears to precede degradation of the transcript. When translation is blocked, this shortening is slowed down and the mRNA is stabilized. This suggests that deadenylation is required before degradation of the mRNA body can take place. (shrink)

This paper argues that mental models of discourse are key in any theory of the interpretation of definite descriptions. It considers both referential and attributive uses of such descriptions, in the sense introduced by Donnellan.

This paper presents a new theory of modal reasoning, i.e. reasoning about what may or may not be the case, and what must or must not be the case. It postulates that individuals construct models of the premises in which they make explicit only what is true. A conclusion is possible if it holds in at least one model, whereas it is necessary if it holds in all the models. The theory makes three predictions, which are corroborated experimentally. First, conclusions (...) correspond to the true, but not the false, components of possibilities. Second, there is a key interaction: it is easier to infer that a situation is possible as opposed to impossible, whereas it is easier to infer that a situation is not necessary as opposed to necessary. Third, individuals make systematic errors of omission and of commission. We contrast the theory with theories based on formal rules. (shrink)

In A.J.P. XXXIII., pp. 426–435, Mr. A. C. Pearson attempted to prove that ὅТαѵ ‘not infrequently bears a causal signification … and that in such cases the temporal meaning is more or less evanescent, and sometimes entirely disappears.’ The use of ὅТαѵ where the verb refers to future time is not discussed, the purpose being ‘to establish that the classification which sums up the other occurrences of the construction as necessarily expressing “indefinite frequency” is incomplete; and that a rigorous insistence (...) on its universal applicability has vitiated the interpretation of numerous passages.’ In the question of ‘causal implication’ I am not particularly interested. It is useless to attempt to deny that our English since is a satisfactory translation of ὅТαѵ in many instances, though it is not, perhaps, an easy matter to state what is the exact force of since in such cases. As to ‘causal implication’ I shall merely point out that a cause, strictly speaking, precedes in time that of which it is the cause, whereas a ὅТε-clause properly defines a situation that is of the same time as the principal clause. The question I wish to raise is whether the implication of ‘indefinite frequency’ has disappeared so completely in certain passages as Mr. Pearson thinks it has. Some of his examples are very interesting. It is not easy to see repeated action in them, and we may admit that critics have not ‘seriously pondered the results which flow from their adherence to established convention.’ But has Mr. Pearson seriously pondered the results which flow from his own conclusions?' So far as I can see, he makes no distinction at all between cases of ὅТαѵ with the subjunctive, ‘where no other relation than that of causality appears to exist between the subordinate and principal clauses’ and cases of ‘causal’ ὅТε with the indicative. (shrink)

This paper reviews the location of Responsible Research and Innovation approaches within the access and benefit sharing policy spaces of the Convention on Biological Diversity and Nagoya Protocol. We describe how a range of dialogues on ethical research practices found a home, almost inadvertently, within the ABS policy process. However, more recent RRI dialogues around emerging technologies have not been similarly absorbed into ABS policy, due in part to the original framing of ABS and associated definitional and scope issues. Consideration (...) is given to the challenges posed to these policy processes by the transformative and rapid nature of scientific and technological change today, including the emerging field of synthetic biology. Drawing on experiences from regulating ABS, we emphasize that the integration of RRI into policies for new, emerging, or poorly understood activities such as synthetic biology faces deficiencies such as limits to government capacity, jurisdictional confusion, shortages in funds, and an absence of strategic approaches. We conclude that a coordinated combination of diverse policy processes within the CBD might provide an invaluable space for RRI dialogues on social justice, sustainability, biosafety, and other issues raised by emerging technologies. (shrink)

This book is an exploration of human understanding, from the perspectives of psychology, philosophy, biology and theology. The six contributors are among the most internationally eminent in their fields. Though scholarly, the writing is non-technical. No background in psychology, philosophy or theology is presumed. No other interdisciplinary work has undertaken to explore the nature of human understanding. This book is unique, and highly significant for anyone interested in or concerned about the human condition.

John Laird was a Scottish philosopher who specialised in metaphysics and moral philosophy. In this early work, which was originally published in 1920, Laird set out to analyse some of the more perplexing problems of philosophical realism. The text includes a brief survey of philosophical realism at the beginning and critical notes throughout. This book will be of value to anyone with an interest in the works of Laird and the history of philosophy.

This article outlines a theory of naive probability. According to the theory, individuals who are unfamiliar with the probability calculus can infer the probabilities of events in an extensional way: They construct mental models of what is true in the various possibilities. Each model represents an equiprobable alternative unless individuals have beliefs to the contrary, in which case some models will have higher probabilities than others. The probability of an event depends on the proportion of models in which it occurs. (...) The theory predicts several phenomena of reasoning about absolute probabilities, including typical biases. It correctly predicts certain cognitive illusions in inferences about relative probabilities. It accommodates reasoning based on numerical premises, and it explains how naive reasoners can infer posterior probabilities without relying on Bayes's theorem. Finally, it dispels some common misconceptions of probabilistic reasoning. (shrink)

I Introduction In recent years there have arisen from several quarters, even within analytic philosophy itself, various challenges to the "positivist" ...

We report three experimental studies of reasoning with double conditionals, i.e. problems based on premises of the form: If A then B. If B then C. where A, B, and C, describe everyday events. We manipulated both the logical structure of the problems, using all four possible arrangements (or ''figures" of their constituents, A, B, and C, and the believability of the two salient conditional conclusions that might follow from them, i.e. If A then C , or If C then (...) A . The experiments showed that with figures for which there was a valid conclusion, the participants more often, and more rapidly, drew the valid conclusion when it was believable than when it was unbelievable. With figures for which there were no valid conclusions, the participants tended to draw whichever of the two conclusions was believable. These results were predicted by the theory that reasoning depends on constructing mental models of the premises. (shrink)

Scientific and technological policy issues are not and should not be exempt from the norms of democratic governance. This article examines two major theories of democracy, analyzes their commonalities and differences, and derives criteria for evaluating various forms of public participation in policymaking. The author argues for a new category of participation, participatory analysis, that includes forms of participation that satisfy democratic criteria and emphasizes the importance of learning among participants. Different types of participatory analysis may be best suited to (...) different kinds of policy problems. (shrink)

Education is on the cusp of a configurational shift, or, as some may argue, in the midst of it. In the last twenty years the direct influence of corporations and their interest in leading educational agencies has substantially increased with no signs of stopping.1 The corporation has become a leader for systemic change in educational practice.2 This systematic change's emphasis on the mighty dollar brings about many different obstacles for educators and educational theorists to consider, one of these being the (...) way education's monetization affects both learners' and educators' motivation. Where does this shift to the focus of funds find such motivations? Looking through the lenses of both John Dewey and... (shrink)

John Laird was a Scottish philosopher who specialised in metaphysics and moral philosophy. In this book, which was first published in 1929, Laird provides a detailed analysis of the philosophical nature of value. The text begins with a discussion of the main definitions of value, before going through a more detailed examination of the various applications of value in turn. This book will appeal to anyone with an interest in value and the history of philosophy.

Classical embryological studies have led to the suggestion that cells in developing tissues may be directed to differentiate along a particular pathway by the concentrations of molecules called morphogens. Studies of the slime mould Dictyostelium discoideum, which has a simple tissue pattern consisting of only two cell types, have revealed several molecules which may act as morphogens. Cyclic AMP and ammonia promote the formation of spores, while adenosine and a novel class of compounds called DIFs promote the formation of stalk (...) cells, the alternative cell fate. The constant proportions of the two differentiated cell types observed in this organism may result from a balance among the influences of these compounds. (shrink)

This article presents a process account of some typicality effects and related similarity-dependent accuracy and response time phenomena that arise in the context of supervised concept acquisition. We describe Symbolic Concept Acquisition (SCA), a computational system that acquires and activates category prediction rules. In contrast to gradient representations, SCA performs by probing for prediction rules in a series of discrete steps. For learning new rules, it acquires general rules but then incrementally learns more specific ones. In describing SCA, we emphasize (...) its functionality in terms of accuracy and efficiency and motivate its design within the set of symbolic mechanisms and memory structures defined by the Soar architecture (Laird, Newell & Rosenbloom, 1987). For replicating human behavior, we first show how SCA exhibits some typicality effects in the course of learning responding faster and more accurately to more typical test examples. Then, using data from human experiments, we evaluate SCA's qualitative predictions on accuracy and response time on individual dataset instances. We show how SCA's predictions correlate with human data across three experimental conditions concerning the effect of instruction on learning strategy. (shrink)